Cargando…

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease

Several microglia-expressed genes have emerged as top risk variants for Alzheimer’s disease (AD). Impaired microglial phagocytosis is one of the main proposed outcomes by which these AD-risk genes may contribute to neurodegeneration, but the mechanisms translating genetic association to cellular dys...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prakash, Priya, Manchanda, Palak, Paouri, Evi, Bisht, Kanchan, Sharma, Kaushik, Wijewardhane, Prageeth R., Randolph, Caitlin E., Clark, Matthew G., Fine, Jonathan, Thayer, Elizabeth A., Crockett, Alexis, Gasmi, Nadia, Stanko, Sarah, Prayson, Richard A., Zhang, Chi, Davalos, Dimitrios, Chopra, Gaurav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274698/ https://www.ncbi.nlm.nih.gov/pubmed/37333071 http://dx.doi.org/10.1101/2023.06.04.543525

Ejemplares similares

Fractalkine regulation of microglial physiology and consequences on the brain and behavior
por: Paolicelli, Rosa Chiara, et al.
Publicado: (2014)

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
por: El Hajj, Hassan, et al.
Publicado: (2019)

Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
por: Tremblay, Marie-Eve, et al.
Publicado: (2016)

A 3′UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice
por: Kalovyrna, Nikoleta, et al.
Publicado: (2020)

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation
por: Loving, Bailey A., et al.
Publicado: (2021)

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible versus resistant male mice upon repeated social defeat
por: González Ibáñez, Fernando, et al.
Publicado: (2023)

Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress
por: Bisht, Kanchan, et al.
Publicado: (2018)

A Comparative Biology of Microglia Across Species
por: Sharma, Kaushik, et al.
Publicado: (2021)

Environmental stimuli shape microglial plasticity in glioma
por: Garofalo, Stefano, et al.
Publicado: (2017)

Dark microglia: Why are they dark?
por: Bisht, Kanchan, et al.
Publicado: (2016)

Lemon: a framework for rapidly mining structural information from the Protein Data Bank
por: Fine, Jonathan, et al.
Publicado: (2019)

Pharmacological Upregulation of Microglial Lipid Droplet Alleviates Neuroinflammation and Acute Ischemic Brain Injury
por: Li, Huiya, et al.
Publicado: (2023)

Glucose Significantly Enhances Enterotoxigenic Escherichia coli Adherence to Intestinal Epithelial Cells through Its Effects on Heat-Labile Enterotoxin Production
por: Wijemanne, Prageeth, et al.
Publicado: (2014)

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice
por: Lee, Jiyeon, et al.
Publicado: (2023)

Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time
por: Prakash, Priya, et al.
Publicado: (2021)

Computational chemoproteomics to understand the role of selected psychoactives in treating mental health indications
por: Fine, Jonathan, et al.
Publicado: (2019)

Accurate Prediction of Inhibitor Binding to HIV-1 Protease Using CANDOCK
por: Falls, Zackary, et al.
Publicado: (2022)

Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment
por: Li, Qing, et al.
Publicado: (2023)

Author Correction: Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice
por: Lee, Jiyeon, et al.
Publicado: (2023)

Risk factors for childhood illness and death in rural Uttar Pradesh, India: perspectives from the community, community health workers and facility staff
por: Srivastava, Kanchan, et al.
Publicado: (2021)

Online medical teaching during COVID-19: Perspectives from teachers and taught
por: Rohila, Jyoti, et al.
Publicado: (2022)

Microglial subtypes: diversity within the microglial community
por: Stratoulias, Vassilis, et al.
Publicado: (2019)

Label-free third harmonic generation imaging and quantification of lipid droplets in live filamentous fungi
por: Pajić, Tanja, et al.
Publicado: (2022)

Spectral deep learning for prediction and prospective validation of functional groups
por: Fine, Jonathan A., et al.
Publicado: (2020)

In vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of fibrinogen deposition in mouse brain
por: Tognatta, Reshmi, et al.
Publicado: (2021)

Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation
por: Kaushik, Deepak Kumar, et al.
Publicado: (2012)

Cadaveric Study on the Morphology and Morphometry of Heart Papillary Muscles
por: Bhadoria, Pooja, et al.
Publicado: (2022)

Microglial pathology
por: Streit, Wolfgang J, et al.
Publicado: (2014)

Dual Pathology in Rasmussen's Encephalitis: A Report of Coexistent Focal Cortical Dysplasia and Review of the Literature
por: Prayson, Richard A.
Publicado: (2012)

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
por: Kaushik, Susmita, et al.
Publicado: (2015)

Combating Ebola with Repurposed Therapeutics Using the CANDO Platform
por: Chopra, Gaurav, et al.
Publicado: (2016)

Is it essential to perform COVID-19 testing prior to ophthalmic procedures?
por: Goel, Ruchi, et al.
Publicado: (2020)

Facile and scalable tubing-free sample loading for droplet microfluidics
por: Shao, Fangchi, et al.
Publicado: (2022)

Modeling of Al and Ga Droplet Nucleation during Droplet Epitaxy or Droplet Etching
por: Heyn, Christian, et al.
Publicado: (2021)

Targeting polyamine biosynthesis to stimulate beta cell regeneration in zebrafish
por: Robertson, Morgan A., et al.
Publicado: (2020)

Condensation of Satellite Droplets on Lubricant-Cloaked Droplets
por: Ge, Qiaoyu, et al.
Publicado: (2020)

The vortex-driven dynamics of droplets within droplets
por: Tiribocchi, A., et al.
Publicado: (2021)

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
por: Sayed, Faten A., et al.
Publicado: (2018)

The Kaleidoscope of Microglial Phenotypes
por: Dubbelaar, Marissa L., et al.
Publicado: (2018)

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
por: Davalos, Dimitrios, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_m9htvusrufcrngh6miaf0kg2j2