The microbial derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota

C. difficile infection (CDI) is associated with antibiotic usage, which disrupts the indigenous gut microbiota and causes the loss of microbial derived secondary bile acids that normally provide protection against C. difficile colonization. Previous work has shown that the secondary bile acid lithoc...

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Detalles Bibliográficos
Autores principales: Kisthardt, Samantha C, Thanissery, Rajani, Pike, Colleen M, Foley, Matthew H, Theriot, Casey M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274734/
https://www.ncbi.nlm.nih.gov/pubmed/37333390
http://dx.doi.org/10.1101/2023.06.06.543867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274734/
https://www.ncbi.nlm.nih.gov/pubmed/37333390
http://dx.doi.org/10.1101/2023.06.06.543867

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