Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function

Due to the importance of 4R tau in the pathogenicity of primary tauopathies, it has been challenging to model these diseases in iPSC-derived neurons, which express very low levels of 4R tau. To address this problem we have developed a panel of isogenic iPSC lines carrying the MAPT splice-site mutati...

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Detalles Bibliográficos
Autores principales: Bowles, KR, Pugh, DA, Pedicone, C, Oja, L, Weitzman, SA, Liu, Y, Chen, JL, Disney, MD, Goate, AM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274740/
https://www.ncbi.nlm.nih.gov/pubmed/37333200
http://dx.doi.org/10.1101/2023.06.02.543224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274740/
https://www.ncbi.nlm.nih.gov/pubmed/37333200
http://dx.doi.org/10.1101/2023.06.02.543224

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