ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes

Congenital heart defects constitute the most common birth defect in humans, affecting approximately 1% of all live births. The incidence of congenital heart defects is exacerbated by maternal conditions, such as diabetes during the first trimester. Our ability to mechanistically understand these dis...

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Detalles Bibliográficos
Autores principales: Kostina, Aleksandra, Lewis-Israeli, Yonatan R., Abdelhamid, Mishref, Gabalski, Mitchell A., Volmert, Brett D., Lankerd, Haley, Huang, Amanda R., Wasserman, Aaron H., Lydic, Todd, Chan, Christina, Olomu, Isoken, Aguirre, Aitor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274758/
https://www.ncbi.nlm.nih.gov/pubmed/37333095
http://dx.doi.org/10.1101/2023.06.07.544081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274758/
https://www.ncbi.nlm.nih.gov/pubmed/37333095
http://dx.doi.org/10.1101/2023.06.07.544081

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