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RETROFIT: Reference-free deconvolution of cell-type mixtures in spatial transcriptomics

Spatial transcriptomics (ST) profiles gene expression in intact tissues. However, ST data measured at each spatial location may represent gene expression of multiple cell types, making it difficult to identify cell-type-specific transcriptional variation across spatial contexts. Existing cell-type d...

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Detalles Bibliográficos
Autores principales: Singh, Roopali, He, Xi, Park, Adam Keebum, Hardison, Ross Cameron, Zhu, Xiang, Li, Qunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274808/
https://www.ncbi.nlm.nih.gov/pubmed/37333291
http://dx.doi.org/10.1101/2023.06.07.544126