Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats

A GGGGCC (G4C2) hexanucleotide repeat expansion in C9ORF72 causes amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), while a CGG trinucleotide repeat expansion in FMR1 leads to the neurodegenerative disorder Fragile X-associated tremor/ataxia syndrome (FXTAS). These GC-rich repea...

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Detalles Bibliográficos
Autores principales: Tseng, Yi-Ju, Malik, Indranil, Deng, Xiexiong, Krans, Amy, Jansen-West, Karen, Tank, Elizabeth M.H., Gomez, Nicolas B., Sher, Roger, Petrucelli, Leonard, Barmada, Sami J., Todd, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274811/
https://www.ncbi.nlm.nih.gov/pubmed/37333274
http://dx.doi.org/10.1101/2023.06.07.544135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274811/
https://www.ncbi.nlm.nih.gov/pubmed/37333274
http://dx.doi.org/10.1101/2023.06.07.544135

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