Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations

Polygenic risk scores (PRS) have improved in predictive performance supporting their use in clinical practice. Reduced predictive performance of PRS in diverse populations can exacerbate existing health disparities. The NHGRI-funded eMERGE Network is returning a PRS-based genome-informed risk assess...

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Detalles Bibliográficos
Autores principales: Lennon, Niall J, Kottyan, Leah C, Kachulis, Christopher, Abul-Husn, Noura, Arias, Josh, Belbin, Gillian, Below, Jennifer E, Berndt, Sonja, Chung, Wendy, Cimino, James J., Clayton, Ellen Wright, Connolly, John J., Crosslin, David, Dikilitas, Ozan, Velez Edwards, Digna R., Feng, QiPing, Fisher, Marissa, Freimuth, Robert, Ge, Tian, Glessner, Joseph T., Gordon, Adam, Guiducci, Candace, Hakonarson, Hakon, Harden, Maegan, Harr, Margaret, Hirschhorn, Joel, Hoggart, Clive, Hsu, Li, Irvin, Ryan, Jarvik, Gail P., Karlson, Elizabeth W., Khan, Atlas, Khera, Amit, Kiryluk, Krzysztof, Kullo, Iftikhar, Larkin, Katie, Limdi, Nita, Linder, Jodell E., Loos, Ruth, Luo, Yuan, Malolepsza, Edyta, Manolio, Teri, Martin, Lisa J., McCarthy, Li, Meigs, James B, Mersha, Tesfaye B., Mosley, Jonathan, Namjou, Bahram, Pai, Nihal, Pesce, Lorenzo L., Peters, Ulrike, Peterson, Josh, Prows, Cynthia A., Puckelwartz, Megan J., Rehm, Heidi, Roden, Dan, Rosenthal, Elisabeth A., Rowley, Robb, Sawicki, Konrad Teodor, Schaid, Dan, Schmidlen, Tara, Smit, Roelof, Smith, Johanna, Smoller, Jordan W., Thomas, Minta, Tiwari, Hemant, Toledo, Diana, Vaitinadin, Nataraja Sarma, Veenstra, David, Walunas, Theresa, Wang, Zhe, Wei, Wei-Qi, Weng, Chunhua, Wiesner, Georgia, Xianyong, Yin, Kenny, Eimear
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275001/
https://www.ncbi.nlm.nih.gov/pubmed/37333246
http://dx.doi.org/10.1101/2023.05.25.23290535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275001/
https://www.ncbi.nlm.nih.gov/pubmed/37333246
http://dx.doi.org/10.1101/2023.05.25.23290535

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