Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis

Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in renal fibrosis. Here, we report the regulation of microRNA-219a-2 (mir-219a-2) by DNA methylation in fibrotic kidneys, unveiling the crosstalk between these epigenetic mechanisms. Through genome-wide DNA methyla...

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Detalles Bibliográficos
Autores principales: Xiao, Xiao, Huo, Emily, Guo, Chunyuan, Zhou, Xiangjun, Hu, Xiaoru, Dong, Charles, Shi, Huidong, Dong, Zheng, Wei, Qingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275039/
https://www.ncbi.nlm.nih.gov/pubmed/37333081
http://dx.doi.org/10.21203/rs.3.rs-2986934/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275039/
https://www.ncbi.nlm.nih.gov/pubmed/37333081
http://dx.doi.org/10.21203/rs.3.rs-2986934/v1

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