Cargando…

Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis

Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in renal fibrosis. Here, we report the regulation of microRNA-219a-2 (mir-219a-2) by DNA methylation in fibrotic kidneys, unveiling the crosstalk between these epigenetic mechanisms. Through genome-wide DNA methyla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Xiao, Huo, Emily, Guo, Chunyuan, Zhou, Xiangjun, Hu, Xiaoru, Dong, Charles, Shi, Huidong, Dong, Zheng, Wei, Qingqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275039/ https://www.ncbi.nlm.nih.gov/pubmed/37333081 http://dx.doi.org/10.21203/rs.3.rs-2986934/v1

Ejemplares similares

Fibronectin, Plasminogen Activator Inhibitor Type 1 (PAI-1) And Uterine Artery Doppler Velocimetry as Markers of Preeclampsia
por: Bodova, Kristina Biskupska, et al.
Publicado: (2011)

miR-34a exerts as a key regulator in the dedifferentiation of osteosarcoma via PAI-1–Sox2 axis
por: Zhang, Yu, et al.
Publicado: (2018)

Novel Function of Cancer Stem Cell Marker ALDH1A3 in Glioblastoma: Pro-Angiogenesis through Paracrine PAI-1 and IL-8
por: Chen, Zhen, et al.
Publicado: (2023)

Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis
por: Topping, Traci, et al.
Publicado: (2022)

Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib
por: Furfaro, A. L., et al.
Publicado: (2016)

PAI-1 but Not PAI-2 Gene Deficiency Attenuates Ischemic Brain Injury After Experimental Stroke
por: Griemert, Eva-Verena, et al.
Publicado: (2018)

Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia
por: Kushwaha, Garima, et al.
Publicado: (2016)

Efficient GSH delivery using PAMAM-GSH into MPP-induced PC12 cellular model for Parkinson’s disease
por: Sun, Hong-Ji, et al.
Publicado: (2016)

Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells
por: Gehlot, Prashasnika, et al.
Publicado: (2016)

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition
por: Sillen, Machteld, et al.
Publicado: (2020)

Aldehyde dehydrogenase 1 (ALDH1) immunostaining in axillary lymph node metastases is an independent prognostic factor in ALDH1-positive breast cancer
por: Guan, Xin, et al.
Publicado: (2021)

Influence of circulating nesfatin-1, GSH and SOD on insulin secretion in the development of T2DM
por: Huang, Kangkang, et al.
Publicado: (2022)

Functional re-evaluation of the putative glutathione transporters, RcGshT and RsGshT.
por: Li, L., et al.
Publicado: (1997)

Comparative Analysis of Bacteriophytochrome Agp2 and Its Engineered Photoactivatable NIR Fluorescent Proteins PAiRFP1 and PAiRFP2
por: Khan, Faez Iqbal, et al.
Publicado: (2020)

MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
por: Yang, Jing, et al.
Publicado: (2018)

Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells
por: Duong, Hong-Quan, et al.
Publicado: (2017)

A Novel Zinc Finger Protein 219-like (ZNF219L) is Involved in the Regulation of Collagen Type 2 Alpha 1a (col2a1a) Gene Expression in Zebrafish Notochord
por: Lien, Huang-Wei, et al.
Publicado: (2013)

Chitosan oligosaccharides alleviate acute heat stress-induced oxidative damage by activating ERK1/2-mediated HO-1 and GSH-Px gene expression in breast muscle of broilers
por: Chang, Qingqing, et al.
Publicado: (2021)

Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts
por: Wang, Mengyi, et al.
Publicado: (2023)

Fibronectin 1: A Potential Biomarker for Ovarian Cancer
por: Bao, Huijing, et al.
Publicado: (2021)

The Glutathione Derivative, GSH Monoethyl Ester, May Effectively Whiten Skin but GSH Does Not
por: Chung, Bo Young, et al.
Publicado: (2016)

Isoflurane Preconditioning Confers Cardioprotection by Activation of ALDH2
por: Lang, Xiao-E, et al.
Publicado: (2013)

Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis
por: Wong, Oscar Gee-Wan, et al.
Publicado: (2010)

Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN)
por: Zhao, Yin, et al.
Publicado: (2020)

ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer
por: Li, Xiao-shan, et al.
Publicado: (2014)

Polonaise op. 219 no. 3 /
por: Popp, Wilhelm

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH(High) Melanoma-Initiating Cells
por: Sarvi, Sana, et al.
Publicado: (2018)

GSH rescue by N-acetylcysteine
por: Ruffmann, R., et al.
Publicado: (1991)

ALDH1 Expression Correlates with Favorable Prognosis in Ovarian Cancers
por: Chang, Bin, et al.
Publicado: (2009)

PAI-1 regulates AT2-mediated re-alveolarization and ion permeability
por: Ali, Gibran, et al.
Publicado: (2023)

PAI-1 regulates AT2-mediated re-alveolarization and ion permeability
por: Ali, Gibran, et al.
Publicado: (2023)

The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
por: Zhang, Hong, et al.
Publicado: (2021)

The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment
por: Sanders, Stephanie, et al.
Publicado: (2021)

The expression of ALDH1 in cervical carcinoma
por: Yao, Tingting, et al.
Publicado: (2011)

ALDH1A3 in CSCs
por: Sullivan, Kelly E., et al.
Publicado: (2017)

Symbolic and quantitative approaches to reasoning with uncertainty: 15th European conference, ECSQARU 219, Belgrade, Serbia, September 18-2, 219, proceedings
por: Kern-Isberner, Gabriele, et al.
Publicado: (2019)

The Effect of PAI-1 Gene Variants and PAI-1 Plasma Levels on Development of Thrombophilia in Patients With Klinefelter Syndrome
por: Erkal, Burcin, et al.
Publicado: (2018)

Prognostic value of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in breast carcinomas.
por: Bouchet, C., et al.
Publicado: (1994)

Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice
por: Hirohashi, Kenshiro, et al.
Publicado: (2020)

ALDH2 variance in disease and populations
por: Chen, Che-Hong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mrgcui76ddq3dl00733c31gdrj