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Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer’s disease

The integration of quantitative trait loci (QTL) with disease genome-wide association studies (GWAS) has proven successful at prioritizing candidate genes at disease-associated loci. QTL mapping has mainly been focused on multi-tissue expression QTL or plasma protein QTL (pQTL). Here we generated th...

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Detalles Bibliográficos
Autores principales: Cruchaga, Carlos, Western, Dan, Timsina, Jigyasha, Wang, Lihua, Wang, Ciyang, Yang, Chengran, Ali, Muhammad, Beric, Aleksandra, Gorijala, Priyanka, Kohlfeld, Patsy, Budde, John, Levey, Allan, Morris, John, Perrin, Richard, Ruiz, Agustín, Marquié, Marta, Boada, Mercè, de Rojas, Itziar, Rutledge, Jarod, Oh, Hamilton, Wilson, Edward, Guen, Yann Le, Alvarez, Ignacio, Aguilar, Miquel, Greicius, Michael, Pastor, Pau, Pulford, David, Ibanez, Laura, Wyss-Coray, Tony, Sung, Yun Ju, Phillips, Bridget
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275048/
https://www.ncbi.nlm.nih.gov/pubmed/37333337
http://dx.doi.org/10.21203/rs.3.rs-2814616/v1