Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation

Obesity is a major risk factor for cardiovascular disease, stroke, and type 2 diabetes (T2D). Excessive accumulation of fat in the abdomen further increases T2D risk. Abdominal obesity is measured by calculating the ratio of waist-to-hip circumference adjusted for the body-mass index (WHRadjBMI), a...

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Detalles Bibliográficos
Autores principales: Aberra, Yonathan Tamrat, Ma, Lijiang, Björkegren, Johan LM, Civelek, Mete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275637/
https://www.ncbi.nlm.nih.gov/pubmed/37326626
http://dx.doi.org/10.7554/eLife.79834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275637/
https://www.ncbi.nlm.nih.gov/pubmed/37326626
http://dx.doi.org/10.7554/eLife.79834

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