Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix

Highly desmoplastic and immunosuppressive tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) contributes to tumor progression and resistance to current therapies. Clues targeting the notorious stromal environment have offered hope for improving therapeutic response whereas the u...

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Detalles Bibliográficos
Autores principales: Duan, Yi, Zhang, Xiaozhen, Ying, Honggang, Xu, Jian, Yang, Hanshen, Sun, Kang, He, Lihong, Li, Muchun, Ji, Yongtao, Liang, Tingbo, Bai, Xueli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275759/
https://www.ncbi.nlm.nih.gov/pubmed/37156839
http://dx.doi.org/10.1038/s41388-023-02711-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275759/
https://www.ncbi.nlm.nih.gov/pubmed/37156839
http://dx.doi.org/10.1038/s41388-023-02711-9

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