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Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19

BACKGROUND: The coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus can lead to serious complications such as respiratory failure, requiring mechanical ventilation or ICU care, and can even result in death, especially in older patients with comorbidities. The ratio of triglyceride to...

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Autores principales: Chang, Yoonkyung, Jeon, Jimin, Song, Tae-Jin, Kim, Jinkwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275776/
https://www.ncbi.nlm.nih.gov/pubmed/37366523
http://dx.doi.org/10.1016/j.heliyon.2023.e17428
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author Chang, Yoonkyung
Jeon, Jimin
Song, Tae-Jin
Kim, Jinkwon
author_facet Chang, Yoonkyung
Jeon, Jimin
Song, Tae-Jin
Kim, Jinkwon
author_sort Chang, Yoonkyung
collection PubMed
description BACKGROUND: The coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus can lead to serious complications such as respiratory failure, requiring mechanical ventilation or ICU care, and can even result in death, especially in older patients with comorbidities. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL), a biomarker of atherosclerotic dyslipidemia and insulin resistance, is related to cardiovascular mortality and morbidity. We aimed to evaluate the link between serious complications of COVID-19 and TG/HDL in the general population. METHODS: We conducted a comprehensive analysis of 3,933 COVID-19 patients from a nationwide cohort in Korea spanning from January 1 to June 4, 2020. TG/HDL ratio was calculated from the national health screening examination data underwent before the COVID-19 infection. Serious complications of COVID-19 were defined as a composite of high-flow oxygen therapy, mechanical ventilation, admission to the intensive care unit (ICU), and mortality. We employed logistic regression analysis to investigate the relationship between the TG/HDL ratio and the likelihood of developing severe complications within 2 months of the diagnosis. To visualize this association, we used a smoothing spline plot based on the generalized additive regression model. Multivariate analysis was performed with adjustment for age, gender, body mass index, lifestyle measures, and comorbidities. RESULTS: Among the 3,933 COVID-19 patients, the proportion of serious complications was 7.53%. Regarding individual outcomes, the number of patients who received high-flow oxygen therapy, mechanical ventilation, ICU care, and died was 84 (2.14%), 122 (3.10%), 173 (4.40%), and 118 (3.00%), respectively. In the multivariable logistic regression, a positive association was found between TG/HDL ratio and serious complications of COVID-19 (adjusted OR, 1.09; 95% CI [1.03–1.15], p = 0.004). CONCLUSION: Our study revealed a significant positive association between TG/HDL ratio and the risk of developing severe complications in COVID-19-infected patients. While this finding provides valuable insight into the potential prognostic role of TG/HDL ratio in COVID-19, further studies are needed to fully elucidate the underlying mechanisms behind this relationship.
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spelling pubmed-102757762023-06-21 Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19 Chang, Yoonkyung Jeon, Jimin Song, Tae-Jin Kim, Jinkwon Heliyon Research Article BACKGROUND: The coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus can lead to serious complications such as respiratory failure, requiring mechanical ventilation or ICU care, and can even result in death, especially in older patients with comorbidities. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL), a biomarker of atherosclerotic dyslipidemia and insulin resistance, is related to cardiovascular mortality and morbidity. We aimed to evaluate the link between serious complications of COVID-19 and TG/HDL in the general population. METHODS: We conducted a comprehensive analysis of 3,933 COVID-19 patients from a nationwide cohort in Korea spanning from January 1 to June 4, 2020. TG/HDL ratio was calculated from the national health screening examination data underwent before the COVID-19 infection. Serious complications of COVID-19 were defined as a composite of high-flow oxygen therapy, mechanical ventilation, admission to the intensive care unit (ICU), and mortality. We employed logistic regression analysis to investigate the relationship between the TG/HDL ratio and the likelihood of developing severe complications within 2 months of the diagnosis. To visualize this association, we used a smoothing spline plot based on the generalized additive regression model. Multivariate analysis was performed with adjustment for age, gender, body mass index, lifestyle measures, and comorbidities. RESULTS: Among the 3,933 COVID-19 patients, the proportion of serious complications was 7.53%. Regarding individual outcomes, the number of patients who received high-flow oxygen therapy, mechanical ventilation, ICU care, and died was 84 (2.14%), 122 (3.10%), 173 (4.40%), and 118 (3.00%), respectively. In the multivariable logistic regression, a positive association was found between TG/HDL ratio and serious complications of COVID-19 (adjusted OR, 1.09; 95% CI [1.03–1.15], p = 0.004). CONCLUSION: Our study revealed a significant positive association between TG/HDL ratio and the risk of developing severe complications in COVID-19-infected patients. While this finding provides valuable insight into the potential prognostic role of TG/HDL ratio in COVID-19, further studies are needed to fully elucidate the underlying mechanisms behind this relationship. Elsevier 2023-06-17 /pmc/articles/PMC10275776/ /pubmed/37366523 http://dx.doi.org/10.1016/j.heliyon.2023.e17428 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Chang, Yoonkyung
Jeon, Jimin
Song, Tae-Jin
Kim, Jinkwon
Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
title Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
title_full Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
title_fullStr Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
title_full_unstemmed Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
title_short Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
title_sort association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275776/
https://www.ncbi.nlm.nih.gov/pubmed/37366523
http://dx.doi.org/10.1016/j.heliyon.2023.e17428
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