Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions

Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious, almost all protein-coding genes lack detectable signals of negative selection. This raises the question of how tumors tolerate such large amounts of delet...

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Detalles Bibliográficos
Autores principales: Alfieri, Fabio, Caravagna, Giulio, Schaefer, Martin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276008/
https://www.ncbi.nlm.nih.gov/pubmed/37328455
http://dx.doi.org/10.1038/s41467-023-39313-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276008/
https://www.ncbi.nlm.nih.gov/pubmed/37328455
http://dx.doi.org/10.1038/s41467-023-39313-8

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