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Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions
Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious, almost all protein-coding genes lack detectable signals of negative selection. This raises the question of how tumors tolerate such large amounts of delet...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276008/ https://www.ncbi.nlm.nih.gov/pubmed/37328455 http://dx.doi.org/10.1038/s41467-023-39313-8 |