Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR

Crystal and cryo-EM structures of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) bound with their peptide ligands have been obtained with full-length constructs, indicating that the extracellular domain (ECD) is indispensable for specific ligand binding. This article comp...

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Detalles Bibliográficos
Autores principales: Wang, Huixia, Hu, Wanhui, Xu, Tiandan, Yuan, Ya, Liu, Dongsheng, Wüthrich, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276138/
https://www.ncbi.nlm.nih.gov/pubmed/37332600
http://dx.doi.org/10.1016/j.isci.2023.106918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276138/
https://www.ncbi.nlm.nih.gov/pubmed/37332600
http://dx.doi.org/10.1016/j.isci.2023.106918

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