Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness

Our previous studies support a key role for mitochondrial lipid hydroperoxides as important contributors to denervation-related muscle atrophy, including muscle atrophy associated with aging. Phospholipid hydroperoxide glutathione peroxidase 4 (GPX4) is an essential antioxidant enzyme that directly...

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Detalles Bibliográficos
Autores principales: Czyżowska, Agnieszka, Brown, Jacob, Xu, Hongyang, Sataranatarajan, Kavitha, Kinter, Michael, Tyrell, Victoria J., O'Donnell, Valerie B., Van Remmen, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276143/
https://www.ncbi.nlm.nih.gov/pubmed/37279604
http://dx.doi.org/10.1016/j.redox.2023.102761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276143/
https://www.ncbi.nlm.nih.gov/pubmed/37279604
http://dx.doi.org/10.1016/j.redox.2023.102761

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