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Distant sequence regions of JBP1 contribute to J-DNA binding

Base-J (β-D-glucopyranosyloxymethyluracil) is a modified DNA nucleotide that replaces 1% of thymine in kinetoplastid flagellates. The biosynthesis and maintenance of base-J depends on the base-J-binding protein 1 (JBP1) that has a thymidine hydroxylase domain and a J-DNA-binding domain (JDBD). How t...

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Detalles Bibliográficos
Autores principales: de Vries, Ida, Ammerlaan, Danique, Heidebrecht, Tatjana, Celie, Patrick HN, Geerke, Daan P, Joosten, Robbie P, Perrakis, Anastassis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276184/
https://www.ncbi.nlm.nih.gov/pubmed/37328191
http://dx.doi.org/10.26508/lsa.202302150