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Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue

Proteasomes are large macromolecular complexes with multiple distinct catalytic activities that are each vital to human brain health and disease. Despite their importance, standardized approaches to investigate proteasomes have not been universally adapted. Here, we describe pitfalls and define stra...

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Detalles Bibliográficos
Autores principales: Türker, Fulya, Bharadwaj, Rahul A., Kleinman, Joel E., Weinberger, Daniel R., Hyde, Thomas M., White, Cory J., Williams, Dionna W., Margolis, Seth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276296/
https://www.ncbi.nlm.nih.gov/pubmed/37172721
http://dx.doi.org/10.1016/j.jbc.2023.104811