Synergising single-cell resolution and 4sU labelling boosts inference of transcriptional bursting

Despite the recent rise of RNA-seq datasets combining single-cell (sc) resolution with 4-thiouridine (4sU) labelling, analytical methods exploiting their power to dissect transcriptional bursting are lacking. Here, we present a mathematical model and Bayesian inference implementation to facilitate g...

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Detalles Bibliográficos
Autores principales: Edwards, David M., Davies, Philip, Hebenstreit, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276402/
https://www.ncbi.nlm.nih.gov/pubmed/37328900
http://dx.doi.org/10.1186/s13059-023-02977-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276402/
https://www.ncbi.nlm.nih.gov/pubmed/37328900
http://dx.doi.org/10.1186/s13059-023-02977-y

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