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The inhibition mechanism of the SUR2A-containing K(ATP) channel by a regulatory helix

K(ATP) channels are metabolic sensors for intracellular ATP/ADP ratios, play essential roles in many physiological processes, and are implicated in a spectrum of pathological conditions. SUR2A-containing K(ATP) channels differ from other subtypes in their sensitivity to Mg-ADP activation. However, t...

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Detalles Bibliográficos
Autores principales: Ding, Dian, Hou, Tianyi, Wei, Miao, Wu, Jing-Xiang, Chen, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276813/
https://www.ncbi.nlm.nih.gov/pubmed/37330603
http://dx.doi.org/10.1038/s41467-023-39379-4