Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy

X-linked adrenoleukodystrophy (X-ALD), the most frequent, inherited peroxisomal disease, is caused by mutations in the ABCD1 gene encoding a peroxisomal lipid transporter importing very long-chain fatty acids (VLCFAs) from the cytosol into peroxisomes for degradation via β-oxidation. ABCD1 deficienc...

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Detalles Bibliográficos
Autores principales: Martinović, Ksenija, Bauer, Jan, Kunze, Markus, Berger, Johannes, Forss-Petter, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276915/
https://www.ncbi.nlm.nih.gov/pubmed/37331971
http://dx.doi.org/10.1186/s40478-023-01595-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276915/
https://www.ncbi.nlm.nih.gov/pubmed/37331971
http://dx.doi.org/10.1186/s40478-023-01595-w

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