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Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy

X-linked adrenoleukodystrophy (X-ALD), the most frequent, inherited peroxisomal disease, is caused by mutations in the ABCD1 gene encoding a peroxisomal lipid transporter importing very long-chain fatty acids (VLCFAs) from the cytosol into peroxisomes for degradation via β-oxidation. ABCD1 deficienc...

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Detalles Bibliográficos
Autores principales:	Martinović, Ksenija, Bauer, Jan, Kunze, Markus, Berger, Johannes, Forss-Petter, Sonja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276915/ https://www.ncbi.nlm.nih.gov/pubmed/37331971 http://dx.doi.org/10.1186/s40478-023-01595-w

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