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Whole-Genome Doubling as a source of cancer: how, when, where, and why?

Chromosome instability is a well-known hallmark of cancer, leading to increased genetic plasticity of tumoral cells, which favors cancer aggressiveness, and poor prognosis. One of the main sources of chromosomal instability are events that lead to a Whole-Genome Duplication (WGD) and the subsequentl...

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Detalles Bibliográficos
Autores principales: Sanz-Gómez, Natalia, González-Álvarez, María, De Las Rivas, Javier, de Cárcer, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277508/
https://www.ncbi.nlm.nih.gov/pubmed/37342233
http://dx.doi.org/10.3389/fcell.2023.1209136