Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral

Expanding antiviral treatment options against SARS-CoV-2 remains crucial as the virus evolves under selection pressure which already led to the emergence of several drug resistant strains. Broad spectrum host-directed antivirals (HDA) are promising therapeutic options, however the robust identificat...

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Detalles Bibliográficos
Autores principales: Kelch, Maximilian A., Vera-Guapi, Antonella, Beder, Thomas, Oswald, Marcus, Hiemisch, Alicia, Beil, Nina, Wajda, Piotr, Ciesek, Sandra, Erfle, Holger, Toptan, Tuna, Koenig, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277617/
https://www.ncbi.nlm.nih.gov/pubmed/37342561
http://dx.doi.org/10.3389/fmicb.2023.1193320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277617/
https://www.ncbi.nlm.nih.gov/pubmed/37342561
http://dx.doi.org/10.3389/fmicb.2023.1193320

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