Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches

Sodium-glucose co-transporter type 2 (SGLT 2, gliflozins) inhibitors are potent orally active drugs approved for managing type 2 diabetes. SGLT 2 inhibitors exert a glucose-lowering effect by suppressing sodium-glucose co-transporters 1 and 2 in the intestinal and kidney proximal tubules. In this st...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Xie, Panpan, Li, Yamei, Chen, Zhixing, Shi, Aixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277867/
https://www.ncbi.nlm.nih.gov/pubmed/37342592
http://dx.doi.org/10.3389/fphar.2023.1142003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277867/
https://www.ncbi.nlm.nih.gov/pubmed/37342592
http://dx.doi.org/10.3389/fphar.2023.1142003

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