Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering

Development of medicines using gene editing has been hampered by enzymological and immunological impediments. We described previously the discovery and characterization of improved, novel gene-editing systems from metagenomic data. In this study, we substantially advance this work with three such ge...

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Detalles Bibliográficos
Autores principales: Lamothe, Rebecca C., Storlie, Meghan D., Espinosa, Diego A., Rudlaff, Rachel, Browne, Patrick, Liu, Jason, Rivas, Andres, Devoto, Audra, Oki, Jennifer, Khoubyari, Ashcon, Goltsman, Daniela S. Aliaga, Lin, Jyun-Liang, Butterfield, Cristina N., Brown, Christopher T., Thomas, Brian C., Cost, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277994/
https://www.ncbi.nlm.nih.gov/pubmed/37219969
http://dx.doi.org/10.1089/crispr.2022.0089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277994/
https://www.ncbi.nlm.nih.gov/pubmed/37219969
http://dx.doi.org/10.1089/crispr.2022.0089

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