Application of Enantioselective Sulfur Ylide Epoxidation to a Short Asymmetric Synthesis of Bedaquiline, a Potent Anti-Tuberculosis Drug

[Image: see text] A highly selective asymmetric synthesis of a potent anti-TB drug (−)-bedaquiline is accomplished using sulfur ylide asymmetric epoxidation, employing (+)-isothiocineole as an inexpensive and readily available chiral sulfide. Excellent enantioselectivity (er 96:4) and diastereoselec...

Descripción completa

Detalles Bibliográficos
Autores principales: Bashir, Maryam, Arshad, Muhammad, Begum, Robina, Aggarwal, Varinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278180/
https://www.ncbi.nlm.nih.gov/pubmed/37284829
http://dx.doi.org/10.1021/acs.orglett.3c01286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278180/
https://www.ncbi.nlm.nih.gov/pubmed/37284829
http://dx.doi.org/10.1021/acs.orglett.3c01286

Ejemplares similares