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Application of Enantioselective Sulfur Ylide Epoxidation to a Short Asymmetric Synthesis of Bedaquiline, a Potent Anti-Tuberculosis Drug

[Image: see text] A highly selective asymmetric synthesis of a potent anti-TB drug (−)-bedaquiline is accomplished using sulfur ylide asymmetric epoxidation, employing (+)-isothiocineole as an inexpensive and readily available chiral sulfide. Excellent enantioselectivity (er 96:4) and diastereoselec...

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Detalles Bibliográficos
Autores principales:	Bashir, Maryam, Arshad, Muhammad, Begum, Robina, Aggarwal, Varinder K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278180/ https://www.ncbi.nlm.nih.gov/pubmed/37284829 http://dx.doi.org/10.1021/acs.orglett.3c01286

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