Therapeutic effects of anti‐GM2 CAR‐T cells expressing IL‐7 and CCL19 for GM2‐positive solid cancer in xenograft model

BACKGROUND: While chimeric antigen receptor (CAR)‐T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved. One of the reasons for such hurdle is a lack of suitable CAR targets in solid cancers. METHODS: GM2 is...

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Detalles Bibliográficos
Autores principales: Sasaki, Takahiro, Sakoda, Yukimi, Adachi, Keishi, Tokunaga, Yoshihiro, Tamada, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278466/
https://www.ncbi.nlm.nih.gov/pubmed/37031457
http://dx.doi.org/10.1002/cam4.5907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278466/
https://www.ncbi.nlm.nih.gov/pubmed/37031457
http://dx.doi.org/10.1002/cam4.5907

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