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TP53 mutations predict poor response to immunotherapy in patients with metastatic solid tumors
BACKGROUND: TP53 is the most commonly mutated gene across all cancer types. R175H mutation was considered structural mutation where the mutation causes misfolding of the protein and leads to a significant conformational alterations within p53's DNA binding domain. The aim of this study was to e...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278489/ https://www.ncbi.nlm.nih.gov/pubmed/37081749 http://dx.doi.org/10.1002/cam4.5953 |