Cargando…

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease

Vascular endothelial cells play an important role in maintaining brain health, but their contribution to Alzheimer's disease (AD) is obscured by limited understanding of the cellular heterogeneity in normal aged brain and in disease. To address this, we performed single nucleus RNAseq on tissue...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bryant, Annie, Li, Zhaozhi, Jayakumar, Rojashree, Serrano-Pozo, Alberto, Woost, Benjamin, Hu, Miwei, Woodbury, Maya E., Wachter, Astrid, Lin, Gen, Kwon, Taekyung, Talanian, Robert V., Biber, Knut, Karran, Eric H., Hyman, Bradley T., Das, Sudeshna, Bennett, Rachel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278684/ https://www.ncbi.nlm.nih.gov/pubmed/37208174 http://dx.doi.org/10.1523/JNEUROSCI.0237-23.2023

Ejemplares similares

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
por: Bryant, Annie G., et al.
Publicado: (2020)

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
por: Das, Sudeshna, et al.
Publicado: (2020)

Partial reduction of microglia does not affect tau pathology in aged mice
por: Bennett, Rachel E., et al.
Publicado: (2018)

Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease
por: Bennett, Rachel E., et al.
Publicado: (2018)

APOE and Alzheimer’s Disease: Advances in Genetics, Pathophysiology, and Therapeutic Approaches.
por: Serrano-Pozo, Alberto, et al.
Publicado: (2021)

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
por: Muñoz-Castro, Clara, et al.
Publicado: (2022)

Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging
por: Zwang, Theodore J, et al.
Publicado: (2023)

Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development
por: Biber, Knut, et al.
Publicado: (2019)

Tau reduction in aged mice does not impact Microangiopathy
por: Bennett, Rachel E., et al.
Publicado: (2020)

Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains
por: Gui, Yaxing, et al.
Publicado: (2019)

Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration
por: Noori, Ayush, et al.
Publicado: (2020)

Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum
por: Noori, Ayush, et al.
Publicado: (2021)

Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue
por: Alsema, Astrid M., et al.
Publicado: (2020)

Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue
por: Zwang, Theodore J, et al.
Publicado: (2023)

Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease
por: Viejo, Lucía, et al.
Publicado: (2021)

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
por: Frigerio, Carlo Sala, et al.
Publicado: (2019)

Dramatic technique /
por: Baker, George Pierce, 1866-1935
Publicado: (1976)

Dramatic monologue /
por: Sinfield, Alan
Publicado: (1977)

Drama & the dramatic
por: Dawson, Sam William
Publicado: (1986)

The dramatic experience
Publicado: (1958)

Nuclear dramatics
Publicado: (2009)

Classroom Dramatics
Publicado: (1939)

The Dramatic in Surgery
Publicado: (1930)

Pasteur Dramatized
por: Packard, Francis R.
Publicado: (1919)

Early resuscitation in the emergency room: dramatic effects that we should not ignore
por: Bennett, David
Publicado: (2002)

The dramatic event : an American chronicle /
por: Bentley, Eric, 1916-
Publicado: (1954)

The theatre and dramatic theory
por: Nicoll, Allardyce, 1894-1976
Publicado: (1962)

Balli and dramatic madrigals
por: Monteverdi, Claudio, 1567-1643
Publicado: (1991)

The Dramatic in Gynæcology and Obstetrics
por: Green-Armytage, V. B.
Publicado: (1949)

MEK1/2 activity modulates TREM2 cell surface recruitment
por: Schapansky, Jason, et al.
Publicado: (2020)

The poetical and dramatic works of S. T. Coleridge.
por: Coleridge, Samuel Taylor, 1772-1834
Publicado: (1847)

Dramatic and persistent loss of eyelashes
por: Venneuguès, Rowena Vicencio, et al.
Publicado: (2015)

Acute and dramatic saxophone penis
por: García-Rodrigo, Carlota Gutiérrez, et al.
Publicado: (2015)

The Bristol Medical Dramatic Club
Publicado: (1937)

Dramatic Genetics and the Teachable Moment
por: Mahler, R F
Publicado: (1996)

A dramatic example of pseudodyskinesis of the left ventricle
por: Gottbrecht, Matthew, et al.
Publicado: (2020)

The human image in dramatic literature : essays /
por: Fergusson, Francis
Publicado: (1957)

P02-008 - Dramatic response to canakinumab in MKD
por: Makay, B, et al.
Publicado: (2013)

Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain
por: Biber, Knut, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0cplrm44t47870vd6eo44taqeg