Nuclear factor-Y mediates pancreatic β-cell compensation by repressing reactive oxygen species-induced apoptosis under metabolic stress

BACKGROUND: Pancreatic β-cells elevate insulin production and secretion through a compensatory mechanism to override insulin resistance under metabolic stress conditions. Deficits in β-cell compensatory capacity result in hyperglycemia and type 2 diabetes (T2D). However, the mechanism in the regulat...

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Detalles Bibliográficos
Autores principales: He, Siyuan, Yu, Xiaoqian, Cui, Daxin, Liu, Yin, Yang, Shanshan, Zhang, Hongmei, Hu, Wanxin, Su, Zhiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278746/
https://www.ncbi.nlm.nih.gov/pubmed/37000974
http://dx.doi.org/10.1097/CM9.0000000000002645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278746/
https://www.ncbi.nlm.nih.gov/pubmed/37000974
http://dx.doi.org/10.1097/CM9.0000000000002645

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