Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity

KEY POINTS: Proximal tubule endocytosis of toxins often leads to nephrotoxicity. Inhibition of endocytosis with receptor-associated protein may serve as a clinical approach to reduce or eliminate kidney damage from a potential nephrotoxin. BACKGROUND: Proximal tubules (PTs) are exposed to many exoge...

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Detalles Bibliográficos
Autores principales: Wagner, Mark C., Sandoval, Ruben M., Yadav, Shiv Pratap S., Campos, Silvia B., Rhodes, George J., Phillips, Carrie L., Molitoris, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Nephrology 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278819/
https://www.ncbi.nlm.nih.gov/pubmed/36848531
http://dx.doi.org/10.34067/KID.0000000000000094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278819/
https://www.ncbi.nlm.nih.gov/pubmed/36848531
http://dx.doi.org/10.34067/KID.0000000000000094

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