HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 engages its structurally diverse substrates and how HUWE1 activity is regulated are unknown. Using unbiased quantitative proteomi...

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Detalles Bibliográficos
Autores principales: Monda, Julie K., Ge, Xuezhen, Hunkeler, Moritz, Donovan, Katherine A., Ma, Michelle W., Jin, Cyrus Y., Leonard, Marilyn, Fischer, Eric S., Bennett, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279472/
https://www.ncbi.nlm.nih.gov/pubmed/37167062
http://dx.doi.org/10.1016/j.celrep.2023.112496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279472/
https://www.ncbi.nlm.nih.gov/pubmed/37167062
http://dx.doi.org/10.1016/j.celrep.2023.112496

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