Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA viruses responsible for severe respiratory infections and resulting disease in infants, elderly, and immunocompromised adults(1–3). Therapeutic small molecule inhibitors that bind to the RSV polymerase and inhibit vir...

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Detalles Bibliográficos
Autores principales: Kleiner, Victoria A., O. Fischmann, Thierry, Howe, John A., Beshore, Douglas C., Eddins, Michael J., Hou, Yan, Mayhood, Todd, Klein, Daniel, Nahas, Debbie D., Lucas, Bob J., Xi, He, Murray, Edward, Ma, Daphne Y., Getty, Krista, Fearns, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279679/
https://www.ncbi.nlm.nih.gov/pubmed/37337079
http://dx.doi.org/10.1038/s42003-023-04990-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279679/
https://www.ncbi.nlm.nih.gov/pubmed/37337079
http://dx.doi.org/10.1038/s42003-023-04990-0

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