Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors

Significant progress has been made in asymmetric synthesis through the use of transition metal catalysts combined with Lewis bases. However, the use of a dual catalytic system involving 4-aminopyridine and transition metal has received little attention. Here we show a metal/Lewis base relay catalyti...

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Detalles Bibliográficos
Autores principales: Jiang, Jing, Zhou, Jin, Li, Yang, Peng, Cheng, He, Gu, Huang, Wei, Zhan, Gu, Han, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279699/
https://www.ncbi.nlm.nih.gov/pubmed/37337043
http://dx.doi.org/10.1038/s42004-023-00921-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279699/
https://www.ncbi.nlm.nih.gov/pubmed/37337043
http://dx.doi.org/10.1038/s42004-023-00921-6

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