Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3

PEAK pseudokinases are molecular scaffolds which dimerize to regulate cell migration, morphology, and proliferation, as well as cancer progression. The mechanistic role dimerization plays in PEAK scaffolding remains unclear, as there are no structures of PEAKs in complex with their interactors. Here...

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Detalles Bibliográficos
Autores principales: Torosyan, Hayarpi, Paul, Michael D., Forget, Antoine, Lo, Megan, Diwanji, Devan, Pawłowski, Krzysztof, Krogan, Nevan J., Jura, Natalia, Verba, Kliment A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279700/
https://www.ncbi.nlm.nih.gov/pubmed/37336883
http://dx.doi.org/10.1038/s41467-023-38864-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279700/
https://www.ncbi.nlm.nih.gov/pubmed/37336883
http://dx.doi.org/10.1038/s41467-023-38864-0

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