Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases

INTRODUCTION: Inhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors can also increase radiation-induced antitumor immunity, but the underlying immunomodulating mechanisms remain poorly understood....

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Detalles Bibliográficos
Autores principales: Eek Mariampillai, Adrian, Hauge, Sissel, Kongsrud, Karoline, Syljuåsen, Randi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279842/
https://www.ncbi.nlm.nih.gov/pubmed/37346039
http://dx.doi.org/10.3389/fimmu.2023.1138920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279842/
https://www.ncbi.nlm.nih.gov/pubmed/37346039
http://dx.doi.org/10.3389/fimmu.2023.1138920

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