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Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases

INTRODUCTION: Inhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors can also increase radiation-induced antitumor immunity, but the underlying immunomodulating mechanisms remain poorly understood....

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Detalles Bibliográficos
Autores principales:	Eek Mariampillai, Adrian, Hauge, Sissel, Kongsrud, Karoline, Syljuåsen, Randi G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279842/ https://www.ncbi.nlm.nih.gov/pubmed/37346039 http://dx.doi.org/10.3389/fimmu.2023.1138920

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