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A novel force transduction pathway from a tension sensor to the gate in the mechano-gating of MscL channel

The bacterial mechanosensitive channel of large conductance MscL is activated exclusively by increased tension in the membrane bilayer. Despite many proposed models for MscL opening, its precise mechano-gating mechanism, particularly how the received force at the tension sensor transmits to the gate...

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Detalles Bibliográficos
Autores principales: Sawada, Yasuyuki, Nomura, Takeshi, Martinac, Boris, Sokabe, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279863/
https://www.ncbi.nlm.nih.gov/pubmed/37347044
http://dx.doi.org/10.3389/fchem.2023.1175443