Cargando…
A novel force transduction pathway from a tension sensor to the gate in the mechano-gating of MscL channel
The bacterial mechanosensitive channel of large conductance MscL is activated exclusively by increased tension in the membrane bilayer. Despite many proposed models for MscL opening, its precise mechano-gating mechanism, particularly how the received force at the tension sensor transmits to the gate...
Autores principales: | Sawada, Yasuyuki, Nomura, Takeshi, Martinac, Boris, Sokabe, Masahiro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279863/ https://www.ncbi.nlm.nih.gov/pubmed/37347044 http://dx.doi.org/10.3389/fchem.2023.1175443 |
Ejemplares similares
-
Molecular dynamics study on protein–water interplay in the mechanogating of the bacterial mechanosensitive channel MscL
por: Sawada, Yasuyuki, et al.
Publicado: (2015) -
Structural Dynamics of the MscL C-terminal Domain
por: Bavi, Navid, et al.
Publicado: (2017) -
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels
por: Bavi, Navid, et al.
Publicado: (2016) -
An improved open-channel structure of MscL determined from FRET confocal microscopy and simulation
por: Corry, Ben, et al.
Publicado: (2010) -
Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve
por: Martinac, Adam D., et al.
Publicado: (2017)