TGF‐β‐induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease

PI3K/AKT/mTOR signalling contributes to several cardiovascular disorders. The aim of this study was to examine the PI3K/AKT/mTOR pathway in myxomatous mitral valve disease (MMVD). Double‐immunofluorescence examined expression of PI3K and TGF‐β1 in canine valves. Valve interstitial cells (VICs) from...

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Detalles Bibliográficos
Autores principales: Tang, Qiyu, Markby, Greg R., MacNair, Andrew J., Tang, Keyi, Tkacz, Michal, Parys, Maciej, Phadwal, Kanchan, MacRae, Vicky E., Corcoran, Brendan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280140/
https://www.ncbi.nlm.nih.gov/pubmed/36869852
http://dx.doi.org/10.1111/cpr.13435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280140/
https://www.ncbi.nlm.nih.gov/pubmed/36869852
http://dx.doi.org/10.1111/cpr.13435

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