The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

Mostrar otras versiones (1)

BACKGROUND: As the pandemic evolves, post-acute sequelae of CoV-2 (PASC) including cardiovascular manifestations have emerged as a new health threat. This study aims to study whether the Spike protein plus obesity can exacerbate PASC-related cardiomyopathy. METHODS: A Spike protein-pseudotyped (Spp)...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Xiaoling, Nguyen, Vi, Tsai, Joseph, Gao, Chao, Tian, Yan, Zhang, Yuping, Carver, Wayne, Kiaris, Hippokratis, Cui, Taixing, Tan, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281040/
https://www.ncbi.nlm.nih.gov/pubmed/37348737
http://dx.doi.org/10.1016/j.molmet.2023.101756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281040/
https://www.ncbi.nlm.nih.gov/pubmed/37348737
http://dx.doi.org/10.1016/j.molmet.2023.101756

Ejemplares similares