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Distinct hyperactive RAS/MAPK alleles converge on common GABAergic interneuron core programs

RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. Although the roles of RAS/MAPK genes have been well studied in cancer, less is known about their function during neurodevelopment. There are many genes that work in concert to regulate RAS/MAPK signaling, suggesting th...

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Detalles Bibliográficos
Autores principales: Knowles, Sara J., Stafford, April M., Zaman, Tariq, Angara, Kartik, Williams, Michael R., Newbern, Jason M., Vogt, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281549/
https://www.ncbi.nlm.nih.gov/pubmed/37254876
http://dx.doi.org/10.1242/dev.201371