PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport

The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificities. For example, the change in prescription practic...

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Detalles Bibliográficos
Autores principales: Gomez, Guillermo M., D’Arrigo, Giulia, Sanchez, Cecilia P., Berger, Fiona, Wade, Rebecca C., Lanzer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281575/
https://www.ncbi.nlm.nih.gov/pubmed/37285379
http://dx.doi.org/10.1371/journal.ppat.1011436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281575/
https://www.ncbi.nlm.nih.gov/pubmed/37285379
http://dx.doi.org/10.1371/journal.ppat.1011436

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