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Genetic risk of osteoarthritis operates during human skeletogenesis

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of cartilage within articular joints. Although it is a leading cause of disability, there are no disease-modifying therapies. Evidence is emerging to support the origins of OA in skeletogenesis. Whereas methylation...

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Detalles Bibliográficos
Autores principales: Rice, Sarah J, Brumwell, Abby, Falk, Julia, Kehayova, Yulia S, Casement, John, Parker, Eleanor, Hofer, Ines M J, Shepherd, Colin, Loughlin, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281754/
https://www.ncbi.nlm.nih.gov/pubmed/36209419
http://dx.doi.org/10.1093/hmg/ddac251