Cargando…

Genetic risk of osteoarthritis operates during human skeletogenesis

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of cartilage within articular joints. Although it is a leading cause of disability, there are no disease-modifying therapies. Evidence is emerging to support the origins of OA in skeletogenesis. Whereas methylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rice, Sarah J, Brumwell, Abby, Falk, Julia, Kehayova, Yulia S, Casement, John, Parker, Eleanor, Hofer, Ines M J, Shepherd, Colin, Loughlin, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281754/ https://www.ncbi.nlm.nih.gov/pubmed/36209419 http://dx.doi.org/10.1093/hmg/ddac251

Ejemplares similares

Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues
por: Kehayova, Yulia S., et al.
Publicado: (2023)

Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk
por: Brumwell, Abby, et al.
Publicado: (2022)

Evolution of the osteoblast: skeletogenesis in gar and zebrafish
por: Eames, B Frank, et al.
Publicado: (2012)

Evolution of a Core Gene Network for Skeletogenesis in Chordates
por: Hecht, Jochen, et al.
Publicado: (2008)

Expression of Glycosaminoglycan Epitopes During Zebrafish Skeletogenesis
por: Hayes, Anthony J, et al.
Publicado: (2013)

Genetics of osteoarthritis
por: Aubourg, G., et al.
Publicado: (2022)

BMP action in skeletogenesis involves attenuation of retinoid signaling
por: Hoffman, Lisa M., et al.
Publicado: (2006)

Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis
por: Bandyopadhyay, Amitabha, et al.
Publicado: (2006)

Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP
por: Shepherd, Colin, et al.
Publicado: (2019)

Functional testing of thousands of osteoarthritis-associated variants for regulatory activity
por: Klein, Jason C., et al.
Publicado: (2019)

Regulation of Zebrafish Skeletogenesis by ext2/dackel and papst1/pinscher
por: Clément, Aurélie, et al.
Publicado: (2008)

Overexpression of Bmi1 in Lymphocytes Stimulates Skeletogenesis by Improving the Osteogenic Microenvironment
por: Zhou, Xichao, et al.
Publicado: (2016)

Transcription Factors of the Alx Family: Evolutionarily Conserved Regulators of Deuterostome Skeletogenesis
por: Khor, Jian Ming, et al.
Publicado: (2020)

Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling
por: Chaugule, Sachin, et al.
Publicado: (2021)

Distinct skeletal stem cell types orchestrate long bone skeletogenesis
por: Ambrosi, Thomas H, et al.
Publicado: (2021)

Requirement for Dlgh-1 in Planar Cell Polarity and Skeletogenesis during Vertebrate Development
por: Rivera, Charlene, et al.
Publicado: (2013)

Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874
por: Shepherd, Colin, et al.
Publicado: (2015)

Exploring human genetic skeletal disorders provides important insights into skeletogenesis and elucidates basic developmental signaling pathways
por: Grigelioniene, Giedre, et al.
Publicado: (2020)

SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis
por: Bhattaram, Pallavi, et al.
Publicado: (2014)

Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis
por: Iezaki, Takashi, et al.
Publicado: (2018)

Genetic contribution to osteoarthritis development: current state of evidence
por: Loughlin, John
Publicado: (2015)

Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis
por: Nowlan, Niamh C., et al.
Publicado: (2011)

Retinoic Acid Receptor α Function in Vertebrate Limb Skeletogenesis: a Modulator of Chondrogenesis
por: Cash, David E., et al.
Publicado: (1997)

Swim-Training Changes the Spatio-Temporal Dynamics of Skeletogenesis in Zebrafish Larvae (Danio rerio)
por: Fiaz, Ansa W., et al.
Publicado: (2012)

Gene regulation of adult skeletogenesis in starfish and modifications during gene network co-option
por: Yamazaki, Atsuko, et al.
Publicado: (2021)

Analysis of the DNA-binding properties of Alx1, an evolutionarily conserved regulator of skeletogenesis in echinoderms
por: Guerrero-Santoro, Jennifer, et al.
Publicado: (2021)

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
por: Rushton, Michael D., et al.
Publicado: (2015)

Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC
por: Sorial, A.K., et al.
Publicado: (2020)

The genetics and functional analysis of primary osteoarthritis susceptibility
por: Reynard, Louise N., et al.
Publicado: (2013)

mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression
por: Dai, Qinggang, et al.
Publicado: (2017)

Understanding the Cellular and Molecular Mechanisms That Control Early Cell Fate Decisions During Appendicular Skeletogenesis
por: Marín-Llera, Jessica Cristina, et al.
Publicado: (2019)

Extensive chondroid bone in juvenile duck limbs hints at accelerated growth mechanism in avian skeletogenesis
por: Prondvai, Edina, et al.
Publicado: (2019)

O(2) variant chip to simulate site-specific skeletogenesis from hypoxic bone marrow
por: Kim, Hye-Seon, et al.
Publicado: (2023)

Genetics of osteoarthritis
por: Loughlin, J, et al.
Publicado: (2004)

Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip - an emerging genetic overlap
por: Loughlin, John
Publicado: (2011)

Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A
por: Fernández, Ignacio, et al.
Publicado: (2011)

Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci
por: Rice, Sarah J., et al.
Publicado: (2019)

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant
por: Shepherd, Colin, et al.
Publicado: (2018)

Thyroid Hormones Accelerate Initiation of Skeletogenesis via MAPK (ERK1/2) in Larval Sea Urchins (Strongylocentrotus purpuratus)
por: Taylor, Elias, et al.
Publicado: (2018)

Humble Bones From skeletogenesis to the Utah paradigm of skeletal physiology: A tribute to the memories of Webster S.S. Jee and Harold M. Frost
por: Lyritis, George P.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ug0l3ik6ntb1pojf181hsa334b