Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome

The engagement of a DNA glycosylase with a damaged DNA base marks the initiation of base excision repair. Nucleosome-based packaging of eukaryotic genome obstructs DNA accessibility, and how DNA glycosylases locate the substrate site on nucleosomes is currently unclear. Here, we report cryo-electron...

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Detalles Bibliográficos
Autores principales: Zheng, Lvqin, Tsai, Bin, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281986/
https://www.ncbi.nlm.nih.gov/pubmed/37339965
http://dx.doi.org/10.1038/s41421-023-00560-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281986/
https://www.ncbi.nlm.nih.gov/pubmed/37339965
http://dx.doi.org/10.1038/s41421-023-00560-0

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