Discovery of extended product structural space of the fungal dioxygenase AsqJ

The fungal dioxygenase AsqJ catalyses the conversion of benzo[1,4]diazepine-2,5-diones into quinolone antibiotics. A second, alternative reaction pathway leads to a different biomedically important product class, the quinazolinones. Within this work, we explore the catalytic promiscuity of AsqJ by s...

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Detalles Bibliográficos
Autores principales: Einsiedler, Manuel, Gulder, Tobias A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282068/
https://www.ncbi.nlm.nih.gov/pubmed/37339975
http://dx.doi.org/10.1038/s41467-023-39111-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282068/
https://www.ncbi.nlm.nih.gov/pubmed/37339975
http://dx.doi.org/10.1038/s41467-023-39111-2

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